Transplantation Immunology (HLA)


The Transplantation Immunology Division (TID) at University of Cincinnati’s Hoxworth Blood Center is a state-of-the-art histocompatibility and immunogenetics testing laboratory.

The TID provides testing and consult services for:

  • solid-organ transplant programs
  • hematopoietic stem cell transplant programs
  • transfusion medicine services (platelet refractoriness workups)
  • primary and specialist care (disease association and drug sensitivity testing)
  • clinical trial and basic research 

The Hoxworth TID is accredited by the American Society of Histocompatibility and Immunogenetics (ASHI). View all certifications and registrations

Laboratory Hours

Routine: 5am Monday through 5am Saturday
On-Call Service: available 24/7, including holidays and weekends 


TID Laboratory Office Phone: (513) 558-1500
TID Laboratory Phone: (513) 558-1574
TID On-Call Phone: (513) 526-9057
TID Fax Number: (513) 558-1522

For pricing, turnaround times, and other information, please get in touch with us via the form below:

Laboratory Menu

Antibody Studies

  • Pre-transplant HLA antibodies
  • Post-transplant donor specific antibodies (DSA)
  • Autoantibody panels
  • C1q
  • IgG subtypes (1-4)
  • HLA antibody titers
  • AT1R
  • ETAR
  • Platelet support: HPA & Class I HLA antibody screening/ID

Molecular Testing

  • Intermediate & high resolution HLA typing
  • Engraftment/Chimerism monitoring
  • Molecular ABO typing


  • Flow cytometric crossmatch (Autologous – Recipient baseline)
  • Flow cytometric crossmatch (Allogeneic – Donor/Recipient pair)
  • Virtual crossmatch

Additional Work

  • DNA isolation and storage
  • Serologic ABO typing
  • STAT testing, as needed

TID Leadership

Headshot of Caroline R. Alquist, MD, PhD, F(ACHI)

Caroline R. Alquist, MD, PhD, F(ACHI)

Chief Transplant-Services Officer, Hoxworth Blood Center, University of Cincinnati

Associate Professor, Hoxworth Blood Center Academic Unit & Department of Pathology & Laboratory Medicine, UC College of Medicine

Dr. Alquist a triple-boarded transfusion medicine and histocompatibility pathologist. She serves as Hoxworth Blood Center’s Chief Transplant Services Officer, medical director of their Apheresis Program, and Cincinnati’s only active ASHI-accredited HLA director for their Transplantation Immunology Division. As an active member and committee participant, she regularly contributes to national histocompatibility [Organ Procurement & Transplantation Network (OPTN), College of American Pathologist, American Society for Histocompatibility and Immunogenetics (ASHI)], apheresis [American Society for Apheresis (ASFA)], and cellular therapy (AABB) committees and best practice guidelines.

Headshot of Paul Brailey , CHS (SEOF)

Paul Brailey , CHS (SEOF)

Assistant Director, Hoxworth Blood Center, University of Cincinnati

Headshot of Jenna Murphy, CHS (ACHI)

Jenna Murphy, CHS (ACHI)

Supervisor, Molecular Core, Hoxworth Blood Center, University of Cincinnati

Headshot of Beth Portwood, CHS (ACHI)

Beth Portwood, CHS (ACHI)

Supervisor, HLA Compatibility, Hoxworth Blood Center, University of Cincinnati

Frequently Asked Questions

  • Unlike many Hoxworth Clinical Laboratory Scientist roles, our niche expertise does not require ASCP certification.
  • Applicants must have an Associates, Bachelor's, Master’s or Doctoral degree in a chemical (physical or biological), clinical laboratory science, or medical technology from an accredited institution. Alternatively, if you have lab experience/training and a background that includes >60h of science courses, you may still meet the requirements for hire.
  • We provide on-the-job training to perform high-complexity HLA testing for new hires and encourage eventual histocompatibility technologist and specialist certification through ACHI.
  • We have 3 shifts that cover life-saving services around the clock. Any available positions can be found at: https://jobs.uc.edu/ (search for keyword: Hoxworth)

Transplantation Immunology Division, Hoxworth Blood Center

3130 Highland Avenue, 5TH Floor Rm 5043

Cincinnati OH 45267-0055

Hoxworth Blood Center only performs direct customer invoicing and does not submit to insurance at this time.