Hoxworth

Publications and Patents

Publications

  1. Hegde S, Akbar H, Zheng Y, Cancelas JA, Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Curr Opin Hematol 2018;25(6)500-508. doi: 10.1097/MOH.0000000000000456. PMID: 30281037 PMC6532779
  2. Singh AK, Althoff MJ, Cancelas JA. Signaling pathways regulating hematopoietic stem cell and progenitor aging. Curr Stem Cell Rep 2018;4(2):166-81. PMC6709869
  3. Adori C, Daraio T, Kuiper R, Barde S, Horvathova L, et al. Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging. Sci Adv. 2021;7(30):eabg5733. PMID: 34290096
  4. Fan Y, Teng Y, Loison F, Pang A, Kasorn A, et al. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Sci Transl Med. 2021;13(604):eabb1069.. PMID: 34321317 NIHMS 1734011
  5. Serrano-Lopez J, Hegde S, Kumar S, Serrano J, Fang J, et al. Inflammation rapidly recruits GMP and MDP from bone marrow into regional lymphatics. Elife 2021;10:e66190 66190 PMID: 33830019 PMC8137144
  6. Davis G, York AJ, Bacon WC, Lin SC, McNeal MM, et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS One 2021;16(7):e0254667. PMID: 34260645
  7. Singh AK, Cancelas JA. Mitochondria transfer in bone marrow hematopoietic activity. Curr Stem Cell Rep 2021;7:1-12.
  8. Hegde S, Wellendorf A, Zheng Y, Cancelas JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021;61(2):557-567. PMID: 33247486. NIHMS 1681320 PMC8006927
  9. Prus K, Alquist CR, Cancelas JA, Oh D. Decrease in serum antibodies to SARS-CoV-2 in convalescent plasma donors over time. Transfusion 2021;61(2):651-4. 16172 PMID: 33616966 PMC8014079
  10. Golan K, Singh AK, Kollet O, Bertagna M, Althoff MJ, et al. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood 2020;136(23):2607-19. PMC7735163 [Embargo to 2021/12/03] PMID: 32929449 (Commentary: Méndez-Ferrer S. HSCs revive their niche after transplantation. Blood 2020;136(23):2597-8.)
  11. Nelson AS, Heyenbruch D, Rubinstein JD, Sabulski A, Jodele S, et al. Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. Blood Adv 2020;4(22):5745-5754. PMID: 33216887 PMC7686882
  12. Govindarajah V, Lee J-M, Solomon M, Goddard B, Nayak N, et al. FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia. Blood Adv 2020;4(21):5512-26. 2020 PMID: 33166407 PMC7656925.
  13. Kelly K, Cancelas JA, Szczepiorkowski ZM, Dumont DF, Rugg N, et al. Frozen platelets - Development and future directions. Transfus Med Rev 2020;34(4):286-93. PMID: 33317698
  14. Althoff MJ, Nayak RC, Hegde S, Wellendorf AM, Bohan B, et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood 2020;136(16):1824-1836. PMID: 32483624 PMC7568035 [Embargo to 2021/10/21]
  15. Boucher AA, Luchtman-Jones L, Palumbo JS, Cancelas JA, Abu-El-Haija M, et al. Extreme thrombocytosis after pediatric pancreatectomy with islet autotransplantation is unique compared to other postsplenectomy states. J Pediatr Surg. 2020;55(8):1645-50. PMID: 31677823
  16. Rubinstein JD, Zhu X, Lutzko C, Leemhuis T, Cancelas JA, et al. Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy. Blood Adv 2020;4(14):3252-3257. PMID: 32697816 PMC7391136
  17. DʼAlessandro A, Yoshida T, Nestheide S, Nemkov T, Stocker S, et al. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion. 2020;60(4):786-798. PMID: 32104927 PMC7899235
  18. Gasilina A, Premnauth G, Gurjar P, Biesiada J, Hegde S, et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras- driven cancer models. PLoS One 2020;15(3):e0229801. PMID 32163428, PMC7067412
  19. D'Alessandro A, Yoshida T, Nestheide S, Nemkov T, Stocker S, et al. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion 2020;60(4):786-98. PMID 32104927
  20. Singh AK, Cancelas JA. Gap junctions in the bone marrow lympho-hematopoietic stem cell niche, leukemia progression, and chemoresistance. Int J Mol Sci 2020;21(3). pii: E796. PMID 31991829, PMC7038046
  21. Yazer MH, Spinella PC, Doyle L, Kaufman RM, Dunn R, et al.; Biomedical Excellence for Safer Transfusion Collaborative. Transfusion of uncrossmatched Group O erythrocyte-containing products does not interfere with most ABO typings. Anesthesiology 2020;132(3):525-354. PMID 31789634
  22. Boucher AA, Luchtman-Jones L, Palumbo JS, Cancelas JA, Abu-El-Haija M, et al. Extreme thrombocytosis after pediatric pancreatectomy with islet autotransplantation is unique compared to other postsplenectomy states. J Pediatr Surg 2019. pii: S0022-3468(19)30665-7. PMID 31677823
  23. Yu Y, Choi K, Wu J, Andreassen PR, Dexheimer PJ, et al. NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Acta Neuropathol 2020 ;139(1):157-74. PMID 31664505
  24. Atreya C, Glynn S, Busch M, Kleinman S, Snyder E, et al. Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018. Transfusion 2019 Sep;59(9):3002-25. PMID 31144334, PMC6726584
  25. Nayak RC, Cancelas JA. Ubiquitination is not omnipresent in myeloid leukemia. Haematologica 2019;104(9):1694-6. PMID 31473606, PMC6717589
  26. Trump LR, Nayak RC, Singh AK, Emberesh S, Wellendorf AM, et al. Neutrophils derived from genetically modified human induced pluripotent stem cells circulate and phagocytose bacteria in vivo. Stem Cells Transl Med 2019;8(6):557-67. PMID 30793529, PMC6525559
  27. Cancelas JA. Future of platelet formulations with improved clotting profile: a short review on human safety and efficacy data. Transfusion 2019;59(S2);1467-73. PMID 30980736
  28. Nayak RC, Hegde, S, Althoff MJ, Wellendorf AM, Mohmoud F, et al. The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors. Nat Commun 2019;10(1):46. PMID 30610188, PMC6320370
  29. Hegde S, Akbar H, Zheng Y, Cancelas JA, Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Curr Opin Hematol 2018;25(6)500-508. PMID 30281037, PMC6532779
  30. Singh AK, Althoff MJ, Cancelas JA. Signaling pathways regulating hematopoietic stem cell and progenitor aging. Curr Stem Cell Rep 2018;4(2):166-81. PMC6709869
  31. Serrano-Lopez J1, Cancelas JA. mom knows best: imprinted control of hematopoietic stem cell quiescence. Cell Stem Cell 2016 Feb 4;18(2):158-60. PMID 26849297
  32. Cancelas JA. Granulocyte transfusion: Questions remain. Blood 2015;126(18):2082-3. PMID 26516218, PMC4626251
  33. Slichter SJ, Dumont LJ, Cancelas JA, Jones M, Gernsheimer TB, et al. Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia. Transfusion 2018;58(9):2129-38. PMID 30204953
  34. Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, et al. KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia. Oncotarget 2018;9(51)29665-79. PMID 30038712, PMC604986
  35. Mock DM, Nalbant D, Kyosseva SV, Schmidt RL, An G, et al. Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations. Transfusion 2018;58(8):2068-81. Review. PMID 29770455
  36. Roy S, Rai P, Eiymo Mwa Mpollo MS, Chang KH, Rizvi T, et al. Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy. Am J Hematol 2018;93(7):E177- E181. (Letter) PMC6037553
  37. Fang J, Muto T, Kleppe M, Bolanos LC, Hueneman KM, et al. TRAF6 mediates basal activation of NF-κB necessary for hematopoietic stem cell homeostasis. Cell Rep 2018;22(5):1250-1262. PMID 29386112, PMC5971064
  38. Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, et al. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Exp Hematol 2018;59:40-50.e3. PMID 29288703, PMC5844846
  39. Lee JM, Govindarajah V, Goddard B, Hinge A, Muench DE, et al. Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression. J Exp Med 2018;215(2):627-44. PMID 29282250, PMC5789409
  40. Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, et al. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica 2018;103(1):69-79. PMID 29051279, PMC5777189
  41. Nalbant D, Cancelas JA, Mock DM, Kyosseva SV, Schmidt RLet al. In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage. Transfusion 2018;58:352-8 PMID 29193118, PMC5803343
  42. Noel JG, Ramser BJ, Cancelas JA, McCormack FX, Gardner JC. Thermal injury of the skin induces G-CSF dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice. Exp Hematol 2017;56:16-30. PMID 28867537
  43. Worsham DN, Reems J-A, Szczepiorkowski ZM, McKenna DH, Leemhuis T, Mathew AJ, Cancelas JA, on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative Group. Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T-cell subpopulations. Transfusion 2017;57(6):1555-65. PMID 28453219
  44. Liu S, de Castro LF Jin P, Civini S, Ren J, et al. Manufacturing differences affect human bone marrow stromal cell characteristics and function: comparison of production methods and products from multiple centers. Sci Rep 2017;7:46731. PMID 28447618, PMC5406832
  45. Cancelas JA, Slichter SJ, Rugg N, Pratt PG, Nestheide S, Corson J, Pellham E, Huntington M, Goodrich RP. Red blood cells derived from whole blood treated with riboflavin and ultraviolet light maintain adequate survival in vivo after 21 days of storage. Transfusion 2017;57(5):1218-25. PMID 28369971
  46. Daily K, Ho Sui SJ, Schriml LM, Dexheimer PJ, Salomonis N, et al. Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. Sci Data 2017;4:170030. PMID 28350385, PMC5369318
  47. Kesarwani M, Kincaid Z, Gomaa A, Huber E, Rohrabaugh S, et al. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nat Med 2017;23(4):472-82. PMID 28319094 PMC5424814
  48. Schmidt RL, Mock DM, Franco RS, Cohen RM, North AK, et al. Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on RBC-biotin dose. Transfusion 2017;57(6):1488-96. PMID 28261808
  49. Choi K, Komurov K, Fletcher J, Jousma E, Cancelas JA, et al. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Sci Rep 2017;7:43315. PMID 28256556, PMC5335359
  50. Guidi N, Sacma M, Standker L, Soller K, Marka G, et al. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J 2017;36(7):840-53. PMID 28254837, PMC5376966 (Erratum 2017;36(10):1463. PMID28507084, PMC5430211)
  51. Cancelas JA, Gottschall JL, Rugg N, Graminske S, Schott MA, et al. Red blood cell concentrates treated with the amustaline (S-303) pathogen reduction system and stored for 35 days retain post-transfusion viability: results of a two-centre study. Vox Sang 2017;112(3)210-8. PMID 28220519 (Erratum: Vox Sang 2017;112(5):495 PMID 28727151)
  52. Cancelas JA, Rugg N, Nestheide S, Hill SE, Gorgas GD, et al. The purified vepoloxamer, prevents hemolysis in 42-day stored, DEHP/PVC-free RBC units. Blood Transfus 2017;15 (2):165-71. PMID 28263175, PMC5336339
  53. Cancelas JA, Scott EP, Bill JR. Continuous CD34+ cell collection by a new device is safe and more efficient than by a standard collection procedure: results of a two-center, crossover, randomized trial. Transfusion 2016 Nov;56(11):2824-32. PMID 27589225

To view a complete list of Dr. Cancelas' published works, please visit the NCBI website.

Patents

Platelet Storage Methods and Compositions for Same. Zheng Y, Cancelas J.

US Patent 10405538 September 10, 2019. Publication: US010405538B2

Platelet Storage Methods and Compositions for Same. Zheng Y, Cancelas J.

US Patent 10028503 B2 July 24, 2018. Publication US010028503B2 Jul 24, 2018; US 2018/0139952 A1 May 24, 2018

Compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a RAC inhibitor, a CDC42 inhibitor, a RHOA inhibitor, or a combination thereof. The compositions may further include a pharmaceutically acceptable carrier.

Prolonged Storage of Red Blood Cells and Composition. Hess JR, Greenwalt TJ

Issue Date: November 21, 2000 US Patent # 6150085

Novel additive solutions that are useful for the storage of human red blood cells (RBCs) under refrigerated conditions. Also, a method of using the additive solutions in an appropriate volume to preserve RBCs at about 1 to 6°C for up to 10 weeks. The solutions and processes allow the viable storage of human RBCs for an extended period of time in a solution which is directly infusible in humans.

Preservation and Shelf Life Extension of Blood Cells. Hess JR, Greenwalt TJ

Issue Date: November 20, 2001 US Patent # 6447987

Preservative solutions that extend the useful shelf-life of red cells from the current 6 to 12 weeks. This intellectual property is shared by the US Army and the University of Cincinnati. Implementation is expected to save 600,000 units from outdating annually, to reduce seasonal shortages of blood, and to make autologous donor programs more efficient.

Compositions Substantially Free of Sodium Chloride and Methods fFor tThe Storage of Red Blood Cells. Hess JR, Greenwalt TJ

Issue Date: April 29, 2014 US Patent # 8709707

Composition of a solution for storage of red blood cells consisting essentially of: adenine; dextrose; a non- metabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions.