Hoxworth

Publications and Patents

Publications

1.       Gasilina A, Premnauth G, Gurjar P, Biesiada J, Hegde S, et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras- driven cancer models. PLoS One 2020 Mar 12;15(3):e0229801. PMID 32163428, PMC7067412

2.       D'Alessandro A, Yoshida T, Nestheide S, Nemkov T, Stocker S, et al. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion 2020 Apr;60(4):786-98. PMID 32104927

3.       Singh AK, Cancelas JA. Gap junctions in the bone marrow lympho-hematopoietic stem cell niche, leukemia progression, and chemoresistance. Int J Mol Sci 2020 Jan 25;21(3). pii: E796. PMID 31991829, PMC7038046

4.       Yazer MH, Spinella PC, Doyle L, Kaufman RM, Dunn R, et al.; Biomedical Excellence for Safer Transfusion Collaborative. Transfusion of uncrossmatched Group O erythrocyte-containing products does not interfere with most ABO typings. Anesthesiology 2020 Mar;132(3):525-354. PMID 31789634

5.       Boucher AA, Luchtman-Jones L, Palumbo JS, Cancelas JA, Abu-El-Haija M, et al. Extreme thrombocytosis after pediatric pancreatectomy with islet autotransplantation is unique compared to other postsplenectomy states. J Pediatr Surg 2019 Oct 25. pii: S0022-3468(19)30665-7. PMID 31677823

6.       Yu Y, Choi K, Wu J, Andreassen PR, Dexheimer PJ, et al. NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Acta Neuropathol 2020 Jan;139(1):157-74. PMID 31664505

7.       Atreya C, Glynn S, Busch M, Kleinman S, Snyder E, et al. Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018. Transfusion 2019 Sep;59(9):3002-25. PMID 31144334, PMC6726584

8.       Nayak RC, Cancelas JA. Ubiquitination is not omnipresent in myeloid leukemia. Haematologica 2019 Sep;104(9):1694-6. PMID 31473606, PMC6717589

9.       Trump LR, Nayak RC, Singh AK, Emberesh S, Wellendorf AM, et al. Neutrophils derived from genetically modified human induced pluripotent stem cells circulate and phagocytose bacteria in vivo. Stem Cells Transl Med 2019 Jun;8(6):557-67. PMID 30793529, PMC6525559

10.   Cancelas JA. Future of platelet formulations with improved clotting profile: a short review on human safety and efficacy data. Transfusion 2019 Apr;59(S2);1467-73. PMID 30980736

11.   Nayak RC, Hegde, S, Althoff MJ, Wellendorf AM, Mohmoud F, et al. The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors. Nat Commun 2019 Jan 4;10(1):46. PMID 30610188, PMC6320370

12.   Hegde S, Akbar H, Zheng Y, Cancelas JA, Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Curr Opin Hematol 2018 Nov;25(6)500-508. PMID 30281037, PMC6532779

13.   Singh AK, Althoff MJ, Cancelas JA. Signaling pathways regulating hematopoietic stem cell and progenitor aging. Curr Stem Cell Rep Jun 2018;4(2):166-81. NIHMSID 964465, PMC6709869

14.   Serrano-Lopez J1, Cancelas JA. mom knows best: imprinted control of hematopoietic stem cell quiescence. Cell Stem Cell 2016 Feb 4;18(2):158-60. PMID 26849297

15.   Cancelas JA. Granulocyte transfusion: Questions remain. Blood 2015 Oct 29;126(18):2082-3. PMID 26516218, PMC4626251

16.   Slichter SJ, Dumont LJ, Cancelas JA, Jones M, Gernsheimer TB, et al. Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia. Transfusion 2018 Sep;58(9):2129-38. PMID 30204953

17.   Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, et al. KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia. Oncotarget Jul 3, 2018;9(51)29665-79. PMID 30038712, PMC6049869

18.   Mock DM, Nalbant D, Kyosseva SV, Schmidt RL, An G, et al. Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations. Transfusion Aug 2018;58(8):2068-81. Review. PMID 29770455

19.   Roy S, Rai P, Eiymo Mwa Mpollo MS, Chang KH, Rizvi T, et al. Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy. Am J Hematol Jul 2018;93(7):E177- E181. (Letter) NIHMS961332, PMC6037553

20.   Fang J, Muto T, Kleppe M, Bolanos LC, Hueneman KM, et al. TRAF6 mediates basal activation of NF-κB necessary for hematopoietic stem cell homeostasis. Cell Rep 2018 Jan 30;22(5):1250-1262. PMID 29386112, NIHMS966903, PMC5971064

21.   Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, et al. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Exp Hematol 2018 Mar;59:40-50.e3. PMID 29288703, PMC5844846

22.   Lee JM, Govindarajah V, Goddard B, Hinge A, Muench DE, et al. Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression. J Exp Med 2018 Feb 5;215(2):627-44. PMID 29282250, PMC5789409

23.   Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, et al. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica 2018;103(1):69-79. PMID 29051279, PMC5777189

24.   Nalbant D, Cancelas JA, Mock DM, Kyosseva SV, Schmidt RLet al. In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage. Transfusion 2018;58:352-8 PMID 29193118, PMC5803343

25.   Noel JG, Ramser BJ, Cancelas JA, McCormack FX, Gardner JC. Thermal injury of the skin induces G-CSF dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice. Exp Hematol 2017;56:16-30. PMID 28867537

26.   Worsham DN, Reems J-A, Szczepiorkowski ZM, McKenna DH, Leemhuis T, Mathew AJ, Cancelas JA, on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative Group. Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T-cell subpopulations. Transfusion 2017 Jun;57(6):1555-65. PMID 28453219

27.   Liu S, de Castro LF Jin P, Civini S, Ren J, et al. Manufacturing differences affect human bone marrow stromal cell characteristics and function: comparison of production methods and products from multiple centers. Sci Rep 2017 Apr 27;7:46731. PMID 28447618, PMC5406832

28.   Cancelas JA, Slichter SJ, Rugg N, Pratt PG, Nestheide S, Corson J, Pellham E, Huntington M, Goodrich RP. Red blood cells derived from whole blood treated with riboflavin and ultraviolet light maintain adequate survival in vivo after 21 days of storage. Transfusion 2017 May;57(5):1218-25. PMID 28369971

29.   Daily K, Ho Sui SJ, Schriml LM, Dexheimer PJ, Salomonis N, et al. Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. Sci Data 2017 Mar 28;4:170030. PMID 28350385, PMC5369318

30.   Kesarwani M, Kincaid Z, Gomaa A, Huber E, Rohrabaugh S, et al. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nat Med 2017 Apr;23(4):472-82. PMID 28319094 PMC5424814

31.   Schmidt RL, Mock DM, Franco RS, Cohen RM, North AK, et al. Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on RBC-biotin dose. Transfusion 2017;57(6):1488-96. PMID 28261808

32.   Choi K, Komurov K, Fletcher J, Jousma E, Cancelas JA, et al. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Sci Rep 2017 Mar 3;7:43315. PMID 28256556, PMC5335359

33.   Guidi N, Sacma M, Standker L, Soller K, Marka G, et al. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J 2017 May 15;36(7):840-53. PMID 28254837, PMC5376966 (Erratum 2017 May 15;36(10):1463. PMID28507084, PMC5430211)

34.   Cancelas JA, Gottschall JL, Rugg N, Graminske S, Schott MA, et al. Red blood cell concentrates treated with the amustaline (S-303) pathogen reduction system and stored for 35 days retain post-transfusion viability: results of a two-centre study. Vox Sang 2017 Apr;112(3)210-8. PMID 28220519 (Erratum: Vox Sang 2017 Jul;112(5):495 PMID 28727151)

35.   Cancelas JA, Rugg N, Nestheide S, Hill SE, Gorgas GD, et al. The purified vepoloxamer, prevents hemolysis in 42-day stored, DEHP/PVC-free RBC units. Blood Transfus 2017 Mar;15 (2):165-71. PMID 28263175, PMC5336339

36.   Cancelas JA, Scott EP, Bill JR. Continuous CD34+ cell collection by a new device is safe and more efficient than by a standard collection procedure: results of a two-center, crossover, randomized trial. Transfusion 2016 Nov;56(11):2824-32. PMID 27589225

37.   Salomonis N, Dexheimer PJ, Omberg L, Schroll R, Bush S, et al. Integrated genomic analysis of diverse induced pluripotent stem cell from the Progenitor Cell Biology Consortium. Stem Cell Rep 2016 Jul 12;7(1):110-25. PMID 27293150, PMC4944587

38.   Wu J, Keng V, Patmore DM, Kendall JJ, Patel AV, et al. Insertional mutagenesis identifies a STAT3/Arid1b/β-catenin pathway driving neurofibroma initiation. Cell Rep 2016 Mar 1;14(8):1979-90. PMID26904939, NIHMS757281, PMC4782770

39.   Gonzalez-Nieto D, Chang K-H, Fasciani I, Nayak R, Fernadez-Garcia L, et al. Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues. Chapter 2 in KW Jeon (Ed), Int Rev Cell Mol Biol 2015;318:27-62. PMID 26315883

40.   Nayak RC, Trump L, Aronow BJ, Myers K, Mehta P, et al. Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells. J Clin Invest 2015 Aug 3;125(8):3103-16 PMID 26193632, PMC4563755

a.       Cancelas JA, Padmanabhan A, Le T, Ambruso DR, Rugg N, et al. Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial. Transfusion, 2015 Apr;55(4):748-55. PMID 25382805

41.   Dumont LJ*, Cancelas JA*, Maes LA, Rugg N, Whitley P, et al. Overnight, room-temperature hold of whole blood followed by 42-day storage of RBCs in additive solution-7. * co-first authors. Transfusion 2015 Mar;55(3):485-90. PMID 25234026

42.   Cancelas JA, Dumont LJ, Maes LA, Rugg N, Herschel L, et al. Additive solution-7 (AS-7) reduces the red blood cell cold-storage lesion. Transfusion 2015 Mar;55 (3):491-8. PMID 25233911

43.   Dumont LJ*, Cancelas JA*, Maes LA, Rugg N, Whitley P, et al. The bioequivalence of frozen plasma prepared from whole blood held overnight at room temperature compared to fresh-frozen plasma prepared within eight hours of collection. *co-first authors. Transfusion 2015 Mar;55(3):476-84. PMID 25233805

Complete List of Published Work for Dr. Cancelas

Patents

Platelet Storage Methods and Compositions for Same. Zheng Y, Cancelas J.

US Patent 10,405,538 September 10, 2019. Publication: US010405538B2

Platelet Storage Methods and Compositions for Same. Zheng Y, Cancelas J.

US Patent 10,028,503 B2 July 24, 2018. Publication US010028503B2 Jul 24, 2018; US 2018/0139952 A1 May 24, 2018

Compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a RAC inhibitor, a CDC42 inhibitor, a RHOA inhibitor, or a combination thereof. The compositions may further include a pharmaceutically acceptable carrier.

Prolonged Storage of Red Blood Cells and Composition Hess JR, Greenwalt TJ

Issue Date: November 21, 2000 US Patent # 6150085

Novel additive solutions that are useful for the storage of human red blood cells (RBCs) under refrigerated conditions. Also, a method of using the additive solutions in an appropriate volume to preserve RBCs at about 1 to 6°C for up to 10 weeks. The solutions and processes allow the viable storage of human RBCs for an extended period of time in a solution which is directly infusible in humans.

Preservation and Shelf Life Extension of Blood Cells Hess JR, Greenwalt TJ

Issue Date: November 20, 2001 US Patent # 6447987

Preservative solutions that extend the useful shelf-life of red cells from the current 6 to 12 weeks. This intellectual property is shared by the US Army and the University of Cincinnati. Implementation is expected to save 600,000 units from outdating annually, to reduce seasonal shortages of blood, and to make autologous donor programs more efficient.

Compositions Substantially Free of Sodium Chloride and Methods For The Storage of Red Blood Cells Hess JR, Greenwalt TJ

Issue Date: April 29, 2014 US Patent # 8709707

Composition of a solution for storage of red blood cells consisting essentially of: adenine; dextrose; a non- metabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions.